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Huidige projecten en studies

CDL

  • Publicaties 2019

    Smulders MW, Kietselaer BLJH, Wildberger JE, Dagnelie PC, Brunner-La Rocca HP, Mingels AMA, van Cauteren YJM, Theunissen RALJ, Post MJ, Schalla S, van Kuijk SMJ, Das M, Kim RJ, Crijns HJGM, Bekkers SCAM. Initial Imaging-Guided Strategy Versus Routine Care in Patients With Non-ST-Segment Elevation Myocardial Infarction. J Am Coll Cardiol. 2019 Nov 19;74(20):2466-2477.

    Lee KK, Ferry AV, Anand A, Strachan FE, Chapman AR, Kimenai DMMeex SJR, Berry C, Findlay I, Reid A, Cruickshank A, Gray A, Collinson PO, Apple FS, McAllister DA, Maguire D, Fox KAA, Newby DE, Tuck C, Keerie C, Weir CJ, Shah ASV, Mills NL. Sex-Specific Thresholds of High-Sensitivity Troponin in Patients With Suspected Acute Coronary Syndrome. High-STEACS Investigators. J Am Coll Cardiol. 2019 Oct 22;74(16):2032-2043.

    Downes K, Megy K, Duarte D, Vries M, Gebhart J, Hofer S, Shamardina O, Deevi SVV, Stephens J, Mapeta R, Tuna S, Al Hasso N, Besser MW, Cooper N, Daugherty L, Gleadall N, Greene D, Haimel M, Martin H, Papadia S, Revel-Vilk S, Sivapalaratnam S, Symington E, Thomas W, Thys C, Tolios A, Penkett CJ, Ouwehand WH, Abbs S, Laffan MA, Turro E, Simeoni I, Mumford AD, Henskens YMC, Pabinger I, Gomez K, Freson K. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic and platelet disorders. Blood. 2019; 134 (23): 2082-2091. 

    Damoiseaux J, Andrade LEC, Carballo OG, Conrad K, Francescantonio PLC, Fritzler MJ, Garcia de la Torre I, Herold M, Klotz W, Cruvinel WM, Mimori T, von Muhlen C, Satoh M, Chan EK. Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective. Ann Rheum Dis. 2019 Jul;78(7):879-889.

    Gorman K, Meyer E, Grozeva D, Spinelli E, McTague A, Sanchis-Juan A, Carss K, Bryant E, Reich A, Amy L Schneider A et al. Henskens Y (collaborator). Bi-allelic loss-of-function CACNA1B mutations in progressive epilepsy-dyskinesia. Am J Hum Genet. 2019; 104 (5): 948-956.

    Damoiseaux J, Vulsteke JB, Tseng CW, Platteel ACM, Piette Y, Shovman O, Bonroy C, Hamann D, De Langhe E, Musset L, Chen YH, Shoenfeld Y, Allenbach Y, Bossuyt X. Autoantibodies in idiopathic inflammatory myopathies: Clinical associations and laboratory evaluation by mono- and multispecific immunoassays. Autoimmun Rev. 2019 Mar;18(3):293-305.

    Boswijk E, Sanders KJC, Broeders EPM, de Ligt M, Vijgen GHEJ, Havekes B, Mingels AMA, Wierts R, van Marken Lichtenbelt WD, Schrauwen P, Mottaghy FM, Wildberger JE, Bucerius J. TSH suppression aggravates arterial inflammation - an 18F-FDG PET study in thyroid carcinoma patients. Eur J Nucl Med Mol Imaging. 2019 Jul;46(7):1428-1438.

    Vroemen WHM, van Doorn WPTM, Kimenai DM, Wodzig WKWH, de Boer D, Bekers O, Meex SJR. Biotin interference in high-sensitivity cardiac troponin T testing: a real-world evaluation in acute cardiac care. Cardiovasc Res. 2019 Dec 1;115(14):1950-1951.

    Fuchs CJ, Hermans WJH, Holwerda AM, Smeets JSJ, Senden JM, van Kranenburg J, Gijsen AP, Wodzig WKHW, Schierbeek H, Verdijk LB, van Loon LJC. Branched-chain amino acid and branched-chain ketoacid ingestion increases muscle protein synthesis rates in vivo in older adults: a double-blind, randomized trial. Am J Clin Nutr. 2019; 110 (4): 862-872. 

    Simons N, Debray FG, Schaper NC, Kooi ME, Feskens EJM, Hollak CEM, Lindeboom L, Koek GH, Bons JAP, Lefeber DJ, Hodson L, Schalkwijk CG, Stehouwer CDA, Cassiman D, Brouwers MCGJ. Patients with aldolase B deficiency are characterized by an increased intrahepatic triglyceride content. J Clin Endocrinol Metab. 2019 104, 11, p. 5053-5061 9 p. 

    Telgenkamp I, Kusters YHAM, Schalkwijk CG, Houben AJHM, Kooi ME, Lindeboom L, Bons JAP, Schaper NC, Joris PJ, Plat J, Mensink RP, Stehouwer CDA, Brouwers MCGJ. Contribution of Liver Fat to Weight Loss-Induced Changes in Serum Hepatokines: A Randomized Controlled Trial. J Clin Endocrinol Metab. 2019 Jul 1;104(7):2719-2727.

    Ter Beek, O., Pavlenko, D., Suck, M., Helfrich, S., Bolhuis-Versteeg, L., Snisarenko, D., Causserand, C., Bacchin, P., Aimar, P., van Oerle, R., Wetzels, R., Verhezen, P., Henskens, Y. & Stamatialis, D. New membranes based on polyethersulfone - SlipSkin (TM) polymer blends with low fouling and high blood compatibility. Sep Purif Technol 2019; 225: 60-73. 

    Heubel-Moenen FCJI, Henskens YMC, Verhezen PWM, Wetzels RJH, Schouten HC, Beckers EAM. Fibrinolysis in patients with chemotherapy-induced thrombocytopenia and the effect of platelet transfusion. J Thromb Haemost. 2019 Jul;17(7):1073-1084.

    Damen SAJ, Vroemen WHM, Brouwer MA, Mezger STP, Suryapranata H, van Royen N, Bekers O, Meex SJR, Wodzig WKWH, Verheugt FWA, de Boer D, Cramer GE, Mingels AMA. Multi-Site Coronary Vein Sampling Study on Cardiac Troponin T Degradation in Non-ST-Segment-Elevation Myocardial Infarction: Toward a More Specific Cardiac Troponin T Assay. J Am Heart Assoc. 2019 Jul 16;8(14):e012602.

    Holwerda AM, Paulussen KJM, Overkamp M, Goessens JPB, Kramer IF, Wodzig WKWH, Verdijk LB, van Loon LJC. Dose-Dependent Increases in Whole-Body Net Protein Balance and Dietary Protein-Derived Amino Acid Incorporation into Myofibrillar Protein During Recovery from Resistance Exercise in Older Men. J Nutr. 2019. 149(2):221-230.

    Luijten J, van Greevenbroek MMJ, Schaper NC, Meex SJR, van der Steen C, Meijer LJ, de Boer D, de Graaf J, Stehouwer CDA, Brouwers MCGJ. Incidence of cardiovascular disease in familial combined hyperlipidemia: A 15-year follow-up study. Atherosclerosis. 2019 Jan;280:1-6.

    Wijnen P, Drent M, Bekers O, Verschakelen J, Bast A. VKORC1 and CYP2C9 Polymorphisms: A Case Report in a Dutch Family with Pulmonary Fibrosis. Int J Mol Sci. 2019 Mar 7; 20 (5), 1160.

    Jooss NJ, De Simone I, Provenzale I, Fernández DI, Brouns SLN, Farndale RW, Henskens YMC, Kuijpers MJE, Ten Cate H, van der Meijden PEJ, Cavill R, Heemskerk JWM. Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces. Int J Mol Sci. 2019 Jun 7;20(11): 2788.

    Holwerda AM, Paulussen KJM, Overkamp M, Goessens JPB, Kramer IF, Wodzig WKWH, Verdijk LB, de Groot LCPGM, van Loon LJC. Leucine co-ingestion augments the muscle protein synthetic response to the ingestion of 15 g protein following resistance exercise in older men. Am J Physiol Endocrinol Metab. 2019; 317 (3), E473-E482.

    Posthuma, J. J., Posma, J. J. N., van Oerle, R., Leenders, P., van Gorp, R. H., Jaminon, A. M. G., Mackman, N., Heitmeier, S., Schurgers, L. J., ten Cate, H. & Spronk, H. M. H. Targetting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice. Scientific Reports. 2019; (9) 3909.

    Mezger STP, Mingels AMA, Bekers O, Cillero-Pastor B, Heeren RMA. Trends in mass spectrometry imaging for cardiovascular diseases. Anal Bioanal Chem. 2019 Jul;411(17):3709-3720.

    Vries MJA, Macrae F, Nelemans PJ, Kuiper GJAJM, Wetzels RJH, Bowman P, Verhezen PWM, Ten Cate H, Ariëns RAS, Henskens YMC. Assessment and determinants of whole blood and plasma fibrinolysis in patients with mild bleeding symptoms. Thromb Res. 2019 Feb;174:88-94. 

    Posthuma, J. J., Posma, J. J. N., Schep, G., Bender, M. M. H., van Oerle, R., van der Wal, A. C., Ten Cate, H. & Spronk, H. M. H. Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes. Journal of Vascular Surgery. 2019; 69 (4): 1243-1250.

    Moenen FCJI, Vries MJA, Nelemans PJ, van Rooy KJM, Vranken JRRA, Verhezen PWM, Wetzels RJH, Ten Cate H, Schouten HC, Beckers EAM, Henskens YMC. Screening for platelet function disorders with Multiplate and platelet function analyzer. Platelets. 2019;30(1):81-87. 

    Rolf L, Smolders J, van den Ouweland J, Hupperets, R, Damoiseaux J. Correlation of Different Cellular Assays to Analyze T Cell-Related Cytokine Profiles in Vitamin D 3-supplemented Patients With Multiple Sclerosis. Mol Immunol. 2019; 105: 198-204.

    Gulpen AJW, Ten Cate H, Henskens YMC, van Oerle R, Wetzels R, Schalla S, Crijns HJ, Ten Cate-Hoek AJ. The daily practice of direct oral anticoagulant use in patients with atrial fibrillation; an observational cohort study. PLoS One. 2019 Jun 6;14(6):e0217302. 

    Horstman AMH, Backx EMP, Smeets JSJ, Marzuca-Nassr GN, van Kranenburg J, Boer de D, Dolmans J, Snijders T, Verdijk LB, de Groot LCPGM, van Loon LJC. Nandrolone decanoate administration does not attenuate muscle atrophy during a short period of disuse. PLoS One. 2019 Jan 28;14(1): 1-15: e0210823. 

    Hendrix MLE, Bons JAP, Alers NO, Severens-Rijvers CAH, Spaanderman MEA, Al-Nasiry S. Maternal vascular malformation in the placenta is an indicator for fetal growth restriction irrespective of neonatal birthweight. Placenta. 2019 Nov;87:8-15. 

    Jessurun NT, Drent M, van Puijenbroek EP, Bekers O, Wijnen PA, Bast A. Drug-induced interstitial lung disease: role of pharmacogenetics in predicting cytotoxic mechanisms and risks of side effects. Curr Opin Pulm Med. 2019 25 (5), 468-477.

    TeMpOH-1 study Grp & Scheepers, L., Henskens Y. et al. Clinical characteristics of women captured by extending the definition of severe postpartum haemorrhage with 'refractoriness to treatment': a cohort study 17 BMC Pregnancy and Childbirth. 2019; 19 (19): 19-36. 

    Proesmans, V. L. J., Drent, M., Elfferich, M. D. P., Wijnen, P. A. H. M., Jessurun, N. T. & Bast, A. Self-reported Gastrointestinal Side Effects of Antifibrotic Drugs in Dutch Idiopathic Pulmonary Fibrosis patients Lung. 2019; 197 (5): 551-558. 

    Hendrix MLE, Bons JAP, Snellings RRG, Bekers O, van Kuijk SMJ, Spaanderman MEA, Al-Nasiry S. Can Fetal Growth Velocity and First Trimester Maternal Biomarkers Improve the Prediction of Small-for-Gestational Age and Adverse Neonatal Outcome? Fetal Diagn Ther. 2019 46, 4, p. 274-284.

    TeMpOH-Study Grp, Henriquez, D. D. C. A., Bloemenkamp, K. W. M., Loeff, R. M., Zwart, J. J., van Roosmalen, J. J. M., Zwaginga, J. J., van der Bom, J. G., Adriaanse, H. J., van den Akker, E. S. A., Baas, M. I., Bank, C. M. C., van Beek, E., de Boer, B. A., de Boer, K., van der Borden, D. M. R., Bremer, H. A., Brons, J. T. J., Burggraaff, J. M., Ceelie, H. & 31 others, Chon, H., Cikot, J. L. M., Delemarre, F. M. C., Diris, J. H. C., Doesburg-van Kleffens, M., van Dooren, I. M. A., van Duijnhoven, J. L. P., van Dunne, F. M., Duvekot, J. J., Engbers, P., Hulst, M. J. W. V. E., Feitsma, H., Fouraux, M. A., Franssen, M. T. M., Frasa, M. A. M., van Gammeren, A. J., van Gemund, N., van der Graaf, F., de Groot, C. J. M., Hackeng, C. M., van der Ham, D. P., Hanssen, M. J. C. P., Hasaart, T. H. M., Hendriks, H. A., Henskens, Y. M. C., Peters, R. H. M., Pouwels, J. G. J., Verhagen, T. E. M., Visser, H., de Vries, M. J. & de Wit, A. C. Fluid resuscitation during persistent postpartum haemorrhage and maternal outcome: A nationwide cohort study. EJOG 2019; 235: 49-56.

    Kuiper GJAJM, van Egmond LT, Henskens YMC, Roekaerts PM, Maessen JG, Ten Cate H, Buhre WF, Lancé MD. Shifts of Transfusion Demand in Cardiac Surgery After Implementation of Rotational Thromboelastometry-Guided Transfusion Protocols: Analysis of the HEROES-CS (HEmostasis Registry of patiEntS in Cardiac Surgery) Observational, Prospective Open Cohort Database. J Cardiothorac Vasc Anesth. 2019 Feb;33(2):307-317. 

    Krekels JPM, Verhezen PWM, Henskens YMC. Platelet Aggregation in Healthy Participants is Not Affected by Smoking, Drinking Coffee, Consuming a High-Fat Meal, or Performing Physical Exercise. Clin Appl Thromb Hemost. 2019 ;25: 1-9. 

    Hendrix MLE, Palm KCM, Van Kuijk SMJ, Bekers O, Spaanderman MEA, Bons JAP, Al-Nasiry S. Longitudinal changes in placental biomarkers in women with early versus late placental dysfunction. Hypertens Pregnancy. 2019 Nov;38(4):268-277.

    Cheung CY, Chan KM, Wong YT, Chak WL, Bekers O, van Hooff JP. Impact of CYP3A5 Genetic Polymorphism on Intrapatient Variability of Tacrolimus Exposure in Chinese Kidney Transplant Recipients.Transplant Proc. 2019 51, 6, p. 1754-1757 4 p. 

    Voortman, M., De Vries, J., Hendriks, C. M. R., Elfferich, M. D. P., Wijnen, P. A. H. M. & Drent, M. Every congnitive failure in patients suffering from neurosarcoidosis. Sarcoidosis Vasc Diffus Lung Dis. 2019; 36: 2-10.

    Vanderlocht J, van Beers JJBC, Limburg PC, Damoiseaux J, Roozendaal C. Antigen-Specific Detection of Autoantibodies Against Myeloperoxidase (MPO) and Proteinase 3 (PR3). Methods Mol Biol. 2019;1901:153-176. 

    van Beers JJBC, Vanderlocht J, Roozendaal C, Damoiseaux J. Detection of Anti-neutrophil Cytoplasmic Antibodies (ANCA) by Indirect Immunofluorescence. Methods Mol Biol. 2019;1901:47-62. 

    Benedikter, B. J., Bouwman, F. G., Heinzmann, A. C. A., Vajen, T., Mariman, E. C., Wouters, E. F. M., Savelkoul, P. H. M., Koenen, R. R., Rohde, G. G. U., van Oerle, R., Spronk, H. M. & Stassen, F. R. M. Proteomic analysis reveals procoagulant properties of cigarette smoke-induced extracellular vesicles. Journal of Extracellular Vesicles . 2019; 8 (1) 1585163. IF Research output: Contribution to journal › Article › Academic › peer-review.

    Kremers, B. M. M., Birocchi, S., van Oerle, R., Zeerleder, S., Spronk, H. M. H., Mees, B. M. E., Luken, B. M., ten Cate, H. & ten Cate-Hoek, A. J. Searching for a Common Thrombo-Inflammatory Basis in Patients With Deep Vein Thrombosis or Peripheral Artery Disease Frontiers in cardiovascular medicine. 2019; 6: 1-11, Research output: Contribution to journal › Article › Academic › peer-review.

    Peeters FECM, Kietselaer BLJH, Hilderink J, van der Linden N, Niens M, Crijns HJGM, Meex SJR. Biological variation of cardiac markers in patients with aortic valve stenosis. Open Heart. 2019 May 8;6(1):e001040.

    Vroemen WHM, Mezger STP, Masotti S, Clerico A, Bekers O, de Boer D, Mingels A. Cardiac Troponin T: Only Small Molecules in Recreational Runners After Marathon Completion. J Appl Lab Med. 2019 Mar;3(5):909-911. 

    Hwang P, Mingels A, Kavsak PA. High-sensitivity cardiac troponin testing during and after ACS: Complexed or not? Clin Biochem. 2019 Nov;73:32-34. 

    Damoiseaux, J. Response to: 'Revised 2017 international consensus on ANCA testing in small vessel vasculitis: support from an external quality assessment' by Broeders et al 2019, In: Annals of the Rheumatic Diseases. 2019;78 (10): E114. Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review.

    Meroni P, Chan E, Damoiseaux J, Coelho Andrade E, Bossuyt X, Conrad K, Mariette X, Sheldon J, Rönnelid, J Fritzler M, members of the committees. Unending Story of the Indirect Immunofluorescence Assay on HEp-2 Cells: Old Problems and New Solutions? Ann Rheum Dis 2019; 78 (6), e46.

    Smolders J, Damoiseaux J, Hupperets R, Hypercalcaemia Rather Than High Dose Vitamin D3 Supplements Could Exacerbate Multiple Sclerosis. Brain. 2019 Dec 1: 142 (12), e71.

    Damoiseaux, J.G.M.C., B. Meek, and C. Roozendaal (2019). De nieuwe internationale consensus met betrekking tot de ANCA-laboratorium-diagnostiek bij ANCA-geassocieerde vasculitis. Ned. Tijdschr. Allergie, Astma, Klin. Immunol. 19:103-110.

    Damoiseaux, J.G.M.C. (2019). Consensus on ANA patterns (ICAP): from clinical association towards clinical relevance of HEp-2 indirect immunofluorescence patterns. In: “Precision medicine – role of autoantibodies in the prediction and care of autoimmune diseases” Conrad et al Eds. Volume 12: 384-390.

    Damoiseaux, J.G.M.C., J. van Beers, and P. van Paassen (2019). Autoantibodies in disease criteria for systemic autoimmune diseases: developments in the last decade. In: “Mosaic of autoimmunity; the novel factors of autoimmune diseases” Perricone and Shoenfeld, Eds. (London: Academic Press), 81-89.

  • Publicaties 2018

    Smulders MW, Kietselaer BLJH, Wildberger JE, Dagnelie PC, Brunner-La Rocca HP, Mingels AMA, van Cauteren YJM, Theunissen RALJ, Post MJ, Schalla S, van Kuijk SMJ, Das M, Kim RJ, Crijns HJGM, Bekkers SCAM. Initial Imaging-Guided Strategy Versus Routine Care in Patients With Non-ST-Segment Elevation Myocardial Infarction. J Am Coll Cardiol. 2019 Nov 19;74(20):2466-2477.

    Lee KK, Ferry AV, Anand A, Strachan FE, Chapman AR, Kimenai DMMeex SJR, Berry C, Findlay I, Reid A, Cruickshank A, Gray A, Collinson PO, Apple FS, McAllister DA, Maguire D, Fox KAA, Newby DE, Tuck C, Keerie C, Weir CJ, Shah ASV, Mills NL. Sex-Specific Thresholds of High-Sensitivity Troponin in Patients With Suspected Acute Coronary Syndrome. High-STEACS Investigators. J Am Coll Cardiol. 2019 Oct 22;74(16):2032-2043.

    Downes K, Megy K, Duarte D, Vries M, Gebhart J, Hofer S, Shamardina O, Deevi SVV, Stephens J, Mapeta R, Tuna S, Al Hasso N, Besser MW, Cooper N, Daugherty L, Gleadall N, Greene D, Haimel M, Martin H, Papadia S, Revel-Vilk S, Sivapalaratnam S, Symington E, Thomas W, Thys C, Tolios A, Penkett CJ, Ouwehand WH, Abbs S, Laffan MA, Turro E, Simeoni I, Mumford AD, Henskens YMC, Pabinger I, Gomez K, Freson K. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic and platelet disorders. Blood. 2019; 134 (23): 2082-2091. 

    Damoiseaux J, Andrade LEC, Carballo OG, Conrad K, Francescantonio PLC, Fritzler MJ, Garcia de la Torre I, Herold M, Klotz W, Cruvinel WM, Mimori T, von Muhlen C, Satoh M, Chan EK. Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective. Ann Rheum Dis. 2019 Jul;78(7):879-889.

    Gorman K, Meyer E, Grozeva D, Spinelli E, McTague A, Sanchis-Juan A, Carss K, Bryant E, Reich A, Amy L Schneider A et al. Henskens Y (collaborator). Bi-allelic loss-of-function CACNA1B mutations in progressive epilepsy-dyskinesia. Am J Hum Genet. 2019; 104 (5): 948-956.

    Damoiseaux J, Vulsteke JB, Tseng CW, Platteel ACM, Piette Y, Shovman O, Bonroy C, Hamann D, De Langhe E, Musset L, Chen YH, Shoenfeld Y, Allenbach Y, Bossuyt X. Autoantibodies in idiopathic inflammatory myopathies: Clinical associations and laboratory evaluation by mono- and multispecific immunoassays. Autoimmun Rev. 2019 Mar;18(3):293-305.

    Boswijk E, Sanders KJC, Broeders EPM, de Ligt M, Vijgen GHEJ, Havekes B, Mingels AMA, Wierts R, van Marken Lichtenbelt WD, Schrauwen P, Mottaghy FM, Wildberger JE, Bucerius J. TSH suppression aggravates arterial inflammation - an 18F-FDG PET study in thyroid carcinoma patients. Eur J Nucl Med Mol Imaging. 2019 Jul;46(7):1428-1438.

    Vroemen WHM, van Doorn WPTM, Kimenai DM, Wodzig WKWH, de Boer D, Bekers O, Meex SJR. Biotin interference in high-sensitivity cardiac troponin T testing: a real-world evaluation in acute cardiac care. Cardiovasc Res. 2019 Dec 1;115(14):1950-1951.

    Fuchs CJ, Hermans WJH, Holwerda AM, Smeets JSJ, Senden JM, van Kranenburg J, Gijsen AP, Wodzig WKHW, Schierbeek H, Verdijk LB, van Loon LJC. Branched-chain amino acid and branched-chain ketoacid ingestion increases muscle protein synthesis rates in vivo in older adults: a double-blind, randomized trial. Am J Clin Nutr. 2019; 110 (4): 862-872. 

    Simons N, Debray FG, Schaper NC, Kooi ME, Feskens EJM, Hollak CEM, Lindeboom L, Koek GH, Bons JAP, Lefeber DJ, Hodson L, Schalkwijk CG, Stehouwer CDA, Cassiman D, Brouwers MCGJ. Patients with aldolase B deficiency are characterized by an increased intrahepatic triglyceride content. J Clin Endocrinol Metab. 2019 104, 11, p. 5053-5061 9 p. 

    Telgenkamp I, Kusters YHAM, Schalkwijk CG, Houben AJHM, Kooi ME, Lindeboom L, Bons JAP, Schaper NC, Joris PJ, Plat J, Mensink RP, Stehouwer CDA, Brouwers MCGJ. Contribution of Liver Fat to Weight Loss-Induced Changes in Serum Hepatokines: A Randomized Controlled Trial. J Clin Endocrinol Metab. 2019 Jul 1;104(7):2719-2727.

    Ter Beek, O., Pavlenko, D., Suck, M., Helfrich, S., Bolhuis-Versteeg, L., Snisarenko, D., Causserand, C., Bacchin, P., Aimar, P., van Oerle, R., Wetzels, R., Verhezen, P., Henskens, Y. & Stamatialis, D. New membranes based on polyethersulfone - SlipSkin (TM) polymer blends with low fouling and high blood compatibility. Sep Purif Technol 2019; 225: 60-73. 

    Heubel-Moenen FCJI, Henskens YMC, Verhezen PWM, Wetzels RJH, Schouten HC, Beckers EAM. Fibrinolysis in patients with chemotherapy-induced thrombocytopenia and the effect of platelet transfusion. J Thromb Haemost. 2019 Jul;17(7):1073-1084.

    Damen SAJ, Vroemen WHM, Brouwer MA, Mezger STP, Suryapranata H, van Royen N, Bekers O, Meex SJR, Wodzig WKWH, Verheugt FWA, de Boer D, Cramer GE, Mingels AMA. Multi-Site Coronary Vein Sampling Study on Cardiac Troponin T Degradation in Non-ST-Segment-Elevation Myocardial Infarction: Toward a More Specific Cardiac Troponin T Assay. J Am Heart Assoc. 2019 Jul 16;8(14):e012602.

    Holwerda AM, Paulussen KJM, Overkamp M, Goessens JPB, Kramer IF, Wodzig WKWH, Verdijk LB, van Loon LJC. Dose-Dependent Increases in Whole-Body Net Protein Balance and Dietary Protein-Derived Amino Acid Incorporation into Myofibrillar Protein During Recovery from Resistance Exercise in Older Men. J Nutr. 2019. 149(2):221-230.

    Luijten J, van Greevenbroek MMJ, Schaper NC, Meex SJR, van der Steen C, Meijer LJ, de Boer D, de Graaf J, Stehouwer CDA, Brouwers MCGJ. Incidence of cardiovascular disease in familial combined hyperlipidemia: A 15-year follow-up study. Atherosclerosis. 2019 Jan;280:1-6.

    Wijnen P, Drent M, Bekers O, Verschakelen J, Bast A. VKORC1 and CYP2C9 Polymorphisms: A Case Report in a Dutch Family with Pulmonary Fibrosis. Int J Mol Sci. 2019 Mar 7; 20 (5), 1160.

    Jooss NJ, De Simone I, Provenzale I, Fernández DI, Brouns SLN, Farndale RW, Henskens YMC, Kuijpers MJE, Ten Cate H, van der Meijden PEJ, Cavill R, Heemskerk JWM. Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces. Int J Mol Sci. 2019 Jun 7;20(11): 2788.

    Holwerda AM, Paulussen KJM, Overkamp M, Goessens JPB, Kramer IF, Wodzig WKWH, Verdijk LB, de Groot LCPGM, van Loon LJC. Leucine co-ingestion augments the muscle protein synthetic response to the ingestion of 15 g protein following resistance exercise in older men. Am J Physiol Endocrinol Metab. 2019; 317 (3), E473-E482.

    Posthuma, J. J., Posma, J. J. N., van Oerle, R., Leenders, P., van Gorp, R. H., Jaminon, A. M. G., Mackman, N., Heitmeier, S., Schurgers, L. J., ten Cate, H. & Spronk, H. M. H. Targetting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice. Scientific Reports. 2019; (9) 3909.

    Mezger STP, Mingels AMA, Bekers O, Cillero-Pastor B, Heeren RMA. Trends in mass spectrometry imaging for cardiovascular diseases. Anal Bioanal Chem. 2019 Jul;411(17):3709-3720.

    Vries MJA, Macrae F, Nelemans PJ, Kuiper GJAJM, Wetzels RJH, Bowman P, Verhezen PWM, Ten Cate H, Ariëns RAS, Henskens YMC. Assessment and determinants of whole blood and plasma fibrinolysis in patients with mild bleeding symptoms. Thromb Res. 2019 Feb;174:88-94. 

    Posthuma, J. J., Posma, J. J. N., Schep, G., Bender, M. M. H., van Oerle, R., van der Wal, A. C., Ten Cate, H. & Spronk, H. M. H. Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes. Journal of Vascular Surgery. 2019; 69 (4): 1243-1250.

    Moenen FCJI, Vries MJA, Nelemans PJ, van Rooy KJM, Vranken JRRA, Verhezen PWM, Wetzels RJH, Ten Cate H, Schouten HC, Beckers EAM, Henskens YMC. Screening for platelet function disorders with Multiplate and platelet function analyzer. Platelets. 2019;30(1):81-87. 

    Rolf L, Smolders J, van den Ouweland J, Hupperets, R, Damoiseaux J. Correlation of Different Cellular Assays to Analyze T Cell-Related Cytokine Profiles in Vitamin D 3-supplemented Patients With Multiple Sclerosis. Mol Immunol. 2019; 105: 198-204.

    Gulpen AJW, Ten Cate H, Henskens YMC, van Oerle R, Wetzels R, Schalla S, Crijns HJ, Ten Cate-Hoek AJ. The daily practice of direct oral anticoagulant use in patients with atrial fibrillation; an observational cohort study. PLoS One. 2019 Jun 6;14(6):e0217302. 

    Horstman AMH, Backx EMP, Smeets JSJ, Marzuca-Nassr GN, van Kranenburg J, Boer de D, Dolmans J, Snijders T, Verdijk LB, de Groot LCPGM, van Loon LJC. Nandrolone decanoate administration does not attenuate muscle atrophy during a short period of disuse. PLoS One. 2019 Jan 28;14(1): 1-15: e0210823. 

    Hendrix MLE, Bons JAP, Alers NO, Severens-Rijvers CAH, Spaanderman MEA, Al-Nasiry S. Maternal vascular malformation in the placenta is an indicator for fetal growth restriction irrespective of neonatal birthweight. Placenta. 2019 Nov;87:8-15. 

    Jessurun NT, Drent M, van Puijenbroek EP, Bekers O, Wijnen PA, Bast A. Drug-induced interstitial lung disease: role of pharmacogenetics in predicting cytotoxic mechanisms and risks of side effects. Curr Opin Pulm Med. 2019 25 (5), 468-477.

    TeMpOH-1 study Grp & Scheepers, L., Henskens Y. et al. Clinical characteristics of women captured by extending the definition of severe postpartum haemorrhage with 'refractoriness to treatment': a cohort study 17 BMC Pregnancy and Childbirth. 2019; 19 (19): 19-36. 

    Proesmans, V. L. J., Drent, M., Elfferich, M. D. P., Wijnen, P. A. H. M., Jessurun, N. T. & Bast, A. Self-reported Gastrointestinal Side Effects of Antifibrotic Drugs in Dutch Idiopathic Pulmonary Fibrosis patients Lung. 2019; 197 (5): 551-558. 

    Hendrix MLE, Bons JAP, Snellings RRG, Bekers O, van Kuijk SMJ, Spaanderman MEA, Al-Nasiry S. Can Fetal Growth Velocity and First Trimester Maternal Biomarkers Improve the Prediction of Small-for-Gestational Age and Adverse Neonatal Outcome? Fetal Diagn Ther. 2019 46, 4, p. 274-284.

    TeMpOH-Study Grp, Henriquez, D. D. C. A., Bloemenkamp, K. W. M., Loeff, R. M., Zwart, J. J., van Roosmalen, J. J. M., Zwaginga, J. J., van der Bom, J. G., Adriaanse, H. J., van den Akker, E. S. A., Baas, M. I., Bank, C. M. C., van Beek, E., de Boer, B. A., de Boer, K., van der Borden, D. M. R., Bremer, H. A., Brons, J. T. J., Burggraaff, J. M., Ceelie, H. & 31 others, Chon, H., Cikot, J. L. M., Delemarre, F. M. C., Diris, J. H. C., Doesburg-van Kleffens, M., van Dooren, I. M. A., van Duijnhoven, J. L. P., van Dunne, F. M., Duvekot, J. J., Engbers, P., Hulst, M. J. W. V. E., Feitsma, H., Fouraux, M. A., Franssen, M. T. M., Frasa, M. A. M., van Gammeren, A. J., van Gemund, N., van der Graaf, F., de Groot, C. J. M., Hackeng, C. M., van der Ham, D. P., Hanssen, M. J. C. P., Hasaart, T. H. M., Hendriks, H. A., Henskens, Y. M. C., Peters, R. H. M., Pouwels, J. G. J., Verhagen, T. E. M., Visser, H., de Vries, M. J. & de Wit, A. C. Fluid resuscitation during persistent postpartum haemorrhage and maternal outcome: A nationwide cohort study. EJOG 2019; 235: 49-56.

    Kuiper GJAJM, van Egmond LT, Henskens YMC, Roekaerts PM, Maessen JG, Ten Cate H, Buhre WF, Lancé MD. Shifts of Transfusion Demand in Cardiac Surgery After Implementation of Rotational Thromboelastometry-Guided Transfusion Protocols: Analysis of the HEROES-CS (HEmostasis Registry of patiEntS in Cardiac Surgery) Observational, Prospective Open Cohort Database. J Cardiothorac Vasc Anesth. 2019 Feb;33(2):307-317. 

    Krekels JPM, Verhezen PWM, Henskens YMC. Platelet Aggregation in Healthy Participants is Not Affected by Smoking, Drinking Coffee, Consuming a High-Fat Meal, or Performing Physical Exercise. Clin Appl Thromb Hemost. 2019 ;25: 1-9. 

    Hendrix MLE, Palm KCM, Van Kuijk SMJ, Bekers O, Spaanderman MEA, Bons JAP, Al-Nasiry S. Longitudinal changes in placental biomarkers in women with early versus late placental dysfunction. Hypertens Pregnancy. 2019 Nov;38(4):268-277.

    Cheung CY, Chan KM, Wong YT, Chak WL, Bekers O, van Hooff JP. Impact of CYP3A5 Genetic Polymorphism on Intrapatient Variability of Tacrolimus Exposure in Chinese Kidney Transplant Recipients.Transplant Proc. 2019 51, 6, p. 1754-1757 4 p. 

    Voortman, M., De Vries, J., Hendriks, C. M. R., Elfferich, M. D. P., Wijnen, P. A. H. M. & Drent, M. Every congnitive failure in patients suffering from neurosarcoidosis. Sarcoidosis Vasc Diffus Lung Dis. 2019; 36: 2-10.

    Vanderlocht J, van Beers JJBC, Limburg PC, Damoiseaux J, Roozendaal C. Antigen-Specific Detection of Autoantibodies Against Myeloperoxidase (MPO) and Proteinase 3 (PR3). Methods Mol Biol. 2019;1901:153-176. 

    van Beers JJBC, Vanderlocht J, Roozendaal C, Damoiseaux J. Detection of Anti-neutrophil Cytoplasmic Antibodies (ANCA) by Indirect Immunofluorescence. Methods Mol Biol. 2019;1901:47-62. 

    Benedikter, B. J., Bouwman, F. G., Heinzmann, A. C. A., Vajen, T., Mariman, E. C., Wouters, E. F. M., Savelkoul, P. H. M., Koenen, R. R., Rohde, G. G. U., van Oerle, R., Spronk, H. M. & Stassen, F. R. M. Proteomic analysis reveals procoagulant properties of cigarette smoke-induced extracellular vesicles. Journal of Extracellular Vesicles . 2019; 8 (1) 1585163. IF Research output: Contribution to journal › Article › Academic › peer-review.

    Kremers, B. M. M., Birocchi, S., van Oerle, R., Zeerleder, S., Spronk, H. M. H., Mees, B. M. E., Luken, B. M., ten Cate, H. & ten Cate-Hoek, A. J. Searching for a Common Thrombo-Inflammatory Basis in Patients With Deep Vein Thrombosis or Peripheral Artery Disease Frontiers in cardiovascular medicine. 2019; 6: 1-11, Research output: Contribution to journal › Article › Academic › peer-review.

    Peeters FECM, Kietselaer BLJH, Hilderink J, van der Linden N, Niens M, Crijns HJGM, Meex SJR. Biological variation of cardiac markers in patients with aortic valve stenosis. Open Heart. 2019 May 8;6(1):e001040.

    Vroemen WHM, Mezger STP, Masotti S, Clerico A, Bekers O, de Boer D, Mingels A. Cardiac Troponin T: Only Small Molecules in Recreational Runners After Marathon Completion. J Appl Lab Med. 2019 Mar;3(5):909-911. 

    Hwang P, Mingels A, Kavsak PA. High-sensitivity cardiac troponin testing during and after ACS: Complexed or not? Clin Biochem. 2019 Nov;73:32-34. 

    Damoiseaux, J. Response to: 'Revised 2017 international consensus on ANCA testing in small vessel vasculitis: support from an external quality assessment' by Broeders et al 2019, In: Annals of the Rheumatic Diseases. 2019;78 (10): E114. Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review.

    Meroni P, Chan E, Damoiseaux J, Coelho Andrade E, Bossuyt X, Conrad K, Mariette X, Sheldon J, Rönnelid, J Fritzler M, members of the committees. Unending Story of the Indirect Immunofluorescence Assay on HEp-2 Cells: Old Problems and New Solutions? Ann Rheum Dis 2019; 78 (6), e46.

    Smolders J, Damoiseaux J, Hupperets R, Hypercalcaemia Rather Than High Dose Vitamin D3 Supplements Could Exacerbate Multiple Sclerosis. Brain. 2019 Dec 1: 142 (12), e71.

    Damoiseaux, J.G.M.C., B. Meek, and C. Roozendaal (2019). De nieuwe internationale consensus met betrekking tot de ANCA-laboratorium-diagnostiek bij ANCA-geassocieerde vasculitis. Ned. Tijdschr. Allergie, Astma, Klin. Immunol. 19:103-110.

    Damoiseaux, J.G.M.C. (2019). Consensus on ANA patterns (ICAP): from clinical association towards clinical relevance of HEp-2 indirect immunofluorescence patterns. In: “Precision medicine – role of autoantibodies in the prediction and care of autoimmune diseases” Conrad et al Eds. Volume 12: 384-390.

    Damoiseaux, J.G.M.C., J. van Beers, and P. van Paassen (2019). Autoantibodies in disease criteria for systemic autoimmune diseases: developments in the last decade. In: “Mosaic of autoimmunity; the novel factors of autoimmune diseases” Perricone and Shoenfeld, Eds. (London: Academic Press), 81-89.

  • Publicaties 2017

    Van der Linden N, Cornelis T, Kimenai DMKlinkenberg LJJHilderink JM, Lück S, Litjens EJR, Peeters FECMStreng AS, Breidthardt T, van Loon LJC, Bekers O, Kooman JP, Westermark PO, Mueller C, Meex SJR.  Origin of Cardiac Troponin T Elevations in Chronic Kidney Disease.Circulation. 2017;136(11):1073-1075.

    Hadinnapola C, Bleda M, Haimel M, Screaton N. , Henskens Y (collaborator).  Phenotypic Characterization of <i>EIF2AK4</i> Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension. Curculation 2017; 136: 2022-2033.

    Damoiseaux J, Csernok E, Rasmussen N, Cohen Tervaert JW, Bossuyt X Antineutrophil cytoplasmic antibodies: reporting and diagnostic strategies. Ann Rheum Dis. 2017;76(10):e39.

    Damoiseaux J, Csernok E, Rasmussen N, Cohen Tervaert JW, Bossuyt X. Antineutrophil cytoplasmic antibodies: appropriate use and interpretation. Ann Rheum Dis. 2017;76(8):e24.

    Damoiseaux J, Csernok E, Rasmussen N, Moosig F, van Paassen P, Baslund B, Vermeersch P Blockmans D, Cohen Tervaert JW, Bossuyt X. Detection of antineutrophil cytoplasmic antibodies (ANCAs): a multicentre European Vasculitis Study Group (EUVAS) evaluation of the value of indirect immunofluorescence (IIF) versus antigen-specific immunoassays. Ann Rheum Dis. 2017;76(4):647-653.

    Bossuyt X, Cohen Tervaert JW, Arimura Y, Blockmans D, Flores-Suárez LF, Guillevin L, Hellmich B, Jayne D, Jennette JC, Kallenberg CGM, Moiseev S, Novikov P, Radice A, Savige JA, Sinico RA, Specks U, van Paassen P, Zhao MH, Rasmussen N, Damoiseaux J, Csernok E. Position paper: Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis. Nat Rev Rheumatol. 2017;13(11):683-692.

    Carss KJ, Arno G, Erwood M et al, Henskens Y (collaborator)Comprehensive rare variant analysis via whole-genome sequencing to determine the molecular pathology of inherited retinal disease. Am J Hum Genet 2017; 100 (1): 75-90.

    Arno G, Carss KJ, Hull S, Zihni C, Robson AG et al, Henskens Y(collaborator). Biallelic Mutation of ERHGEF18, involved in the determination of epithelial apicobasal polarity, causes adult-onset retinal degeneration. Am J Hum Genet 2017; 100 (2): 334-342.

    Falkenberg, K. D., Braverman, N. E., Moser, A. B., Steinberg, S. J., Klouwer, F. C. C., Schluter, A., Ruiz, M., Pujol, A., Engvall, M., Naess, K., van Spronsen, F., Körver-Keularts, I., Rubio-Gozalbo, M. E., Ferdinandusse, S., Wanders, R. J. A. & Waterham, H. R. Allelic Expression Imbalance Promoting a Mutant PEX6 Allele Causes Zellweger Spectrum Disorder.  Am J of Hum Genet 2017; 101, 6, p. 965-976 12 p.

    Dahan S, Segal Y, Watad A, Azrielant S, Shemer A, Maymon D, Stroev YI, Sobolevskaya PA, Korneva EA, Blank M, Gilburd B, Shovman O, Amital H, Ehrenfeld M, Tanay A, Kivity S, Pras E, Chapman J, Damoiseaux J, Cervera R, Putterman C, Shapiro I, Mouthon L, Perricone R, Bizzaro N, Koren O, Riemekasten G, Chereshnev VA, Mazurov VI, Goloviznin M, Gurevich V, Churilov LP, Shoenfeld Y. Novelties in the field of autoimmunity - 1st Saint Petersburg congress of autoimmunity, the bridge between east and west. Autoimmun Rev. 2017;16(12):1175-1184.

    Timmermans SAMEG, Abdul-Hamid MA, Vanderlocht JDamoiseaux JGMC, Reutelingsperger CP, van Paassen P. Limburg Renal Registry. Patients with hypertension-associated thrombotic microangiopathy may present with complement abnormalities. Kidney Int. 2017;91(6):1420-1425.

    Knippenberg S, Smolders J, van den Maegdenbergh M, Porro G, Damoiseaux J, Hupperts R. Vitamin D status is negatively correlated with retinal nerve fiber layer thickness in relapsing-remitting MS patients without acute optic neuritis. Mult Scler. 2017;23(1):128-129.

    Bossuyt X, Rasmussen N, van Paassen P, Hellmich B, Baslund B, Vermeersch P, Blockmans D, Cohen Tervaert JW, Csernok E, Damoiseaux J. A multicentre study to improve clinical interpretation of proteinase-3 and myeloperoxidase anti-neutrophil cytoplasmic antibodies. Rheumatology (Oxford). 2017;56(9):1533-1541.

    Streng ASde Boer Dvan Doorn WP, Bouwman FG, Mariman EC, Bekers O, van Dieijen-Visser MP,Wodzig WKIdentification and Characterization of Cardiac Troponin T Fragments in Serum of Patients Suffering from Acute Myocardial Infarction.Clin Chem. 2017;63(2):563-572. 

    Mingels AMCardinaels EP, Broers NJ, van Sleeuwen A, Streng AS, van Dieijen-Visser MP, Kooman JP, Bekers OCardiac Troponin T: Smaller Molecules in Patients with End-Stage Renal Disease than after Onset of Acute Myocardial Infarction.Clin Chem. 2017;63(3):683-690.

    Martens RJ, Kimenai DM, Kooman JP, Stehouwer CD, Tan FE, Bekers O, Dagnelie PC, van der Kallen CJ, Kroon AA, Leunissen KM, van der Sande FM, Schaper NC, Sep SJ, Schram MT, van Suijlen JD, van Dieijen-Visser MP,Meex SJ, Henry RM. Estimated Glomerular Filtration Rate and Albuminuria Are Associated with Biomarkers of Cardiac Injury in a Population-Based Cohort Study: The Maastricht Study.  Clin Chem. 2017;63(4):887-897.

    Van der Linden NStreng ASBekers OWodzig WKWHMeex SJRde Boer DLarge Variation in Measured Cardiac Troponin T Concentrations after Standard Addition in Serum or Plasma of Different Individuals.Clin Chem. 2017;63(7):1300-1302.

    Van der Linden NHilderink JM, Cornelis T, Kimenai DMKlinkenberg LJJvan Doorn WP, Litjens EJR, van Suijlen JDE, van Loon LJC, Bekers O, Kooman JP, Meex SJR. Twenty-Four-Hour Biological Variation Profiles of Cardiac Troponin I in Individuals with or without Chronic Kidney Disease. Clin Chem. 2017;63(10):1655-1656.

    Vroemen WHMde Boer DStreng ASBekers OWodzig WKWH. Thrombin Activation via Serum Preparation Is Not the Root Cause for Cardiac Troponin T Degradation. Clin Chem.2017;63(11):1768-1769.

    Kimenai DM, Martens RJH, Kooman JP, Stehouwer CDA, Tan FES, Schaper NC, Dagnelie PC, Schram MT, van der Kallen CJH, Sep SJS, van Suijlen JDE, Kroon AA, Bekers O, van Dieijen-Visser MP, Henry RMA, Meex SJR. Troponin I and T in relation to cardiac injury detected with electrocardiography in a population-based cohort - The Maastricht Study. Sci Rep. 2017; 26;7(1):6610.

    Baumgartner S, Mensink RP, Haenen GR, Bast A, Binder CJ, Bekers O, Husche C, Lütjohann D, Plat J. The effects of vitamin E or lipoic acid supplementation on oxyphytosterols in subjects with elevated oxidative stress: a randomized trial. Sci Rep. 2017;7(1):15288.

    Saxena A, Stevens J, Cetin H, Koneczny I, Webster R, Lazaridis K, Tzartos S, Vrolix K, Nogales-Gadea G, Machiels B, Molenaar PCDamoiseaux J, De Baets MH, Simon-Keller K, Marx A, Vincent A, Losen M, Martinez-Martinez P. Characterization of an anti-fetal AChR monoclonal antibody isolated from a myasthenia gravis patient. Sci Rep. 2017;7(1):14426.

    Adriaanse MPM, Mubarak A, Riedl RG, Ten Kate FJW, Damoiseaux JGMC, Buurman WA, Houwen RHJ, Vreugdenhil ACE; Celiac Disease Study Group. Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP. Sci Rep. 2017;7(1):8671.

    de Jong JJA, Arts JJC, Willems PC, Bours SPG, Bons JPA, Menheere PPCA, van Rietbergen B, Geusens PP, van den Bergh JPW. Contra-lateral bone loss at the distal radius in postmenopausal women after a distal radius fracture: A two-year follow-up HRpQCT study. Bone. 2017;101:245-251.

    Kouw IW, Holwerda AM, Trommelen J, Kramer IF, Bastiaanse J, Halson SL, Wodzig WK, Verdijk LB, van Loon LJ. Protein Ingestion before Sleep Increases Overnight Muscle Protein Synthesis Rates in Healthy Older Men: A Randomized Controlled Trial. J Nutr. 2017;147(12):2252-2261.

    Hilderink JMKlinkenberg LJJ, Aakre KM, de Wit NCJHenskens YMCvan der Linden NBekers O, Rennenberg RJMW, Koopmans RP, Meex SJR. Within-day biological variation and hour-to-hour reference change values for hematological parameters.Clin Chem Lab Med. 2017 27;55(7):1013-1024.

    Mahler M, Damoiseaux J, Ballet V, Dillaerts D, Bentow C, Cohen Tervaert JW, Blockmans D, Boeckxstaens G, Aguilera-Lizarraga J, Csernok E, Vermeire S, Bossuyt X. PR3-anti-neutrophil cytoplasmic antibodies (ANCA) in ulcerative colitis. Clin Chem Lab Med. 2017 Nov 27;56(1):e27-e30.

    Grommé M, Russcher H2, Braakman E3, Klinkspoor JH4, Dobber JA5, de Greef I3, de Wit NCJMulticenter study to evaluate a new enumeration method for hematopoietic stem cell collection management. Transfusion.  2017;57(8):1949-1955. 

    Houben IPL, van Berlo CJLY, Bekers O, Nijssen EC, Lobbes MBI, Wildberger JE. Assessing the Risk of Contrast-Induced Nephropathy Using a Finger Stick Analysis in Recalls from Breast Screening: The CINFIBS Explorative Study. Contrast Media Mol Imaging. 2017:5670384. eCollection 2017. 

    Kemna MJ, Cohen Tervaert JW, Broen K, Timmermans SAMEG, van Paassen P, Damoiseaux JGMC. Seasonal Influence on the Risk of Relapse at a Rise of Antineutrophil Cytoplasmic Antibodies in Vasculitis Patients with Renal Involvement. J Rheumatol. 2017;44(4):473-481.

    Talsness CE, Penders J, Jansen EHJM, Damoiseaux J, Thijs C, Mommers M. Influence of vitamin D on key bacterial taxa in infant microbiota in the KOALA Birth Cohort Study. PLoS One. 2017;12(11):e0188011. eCollection 2017. 

    Kicken CH, Roest M, Henskens YM, de Laat B, Huskens D. Application of an optimized flow cytometry-based quantification of Platelet Activation (PACT): Monitoring platelet activation in platelet concentrates. PLoS One. 2017;12(2):e0172265. eCollection 2017. 

    Van der Leeuw S, Peeters S, Gronenschild E, Michielse S, Verbeek M, Menheere P,  van Os J, Marcelis M. Serum S100B: a proxy marker for grey and white matter status in the absence and presence of (increased risk of) psychotic disorder? Risk and outcome in psychosis (G.R.O.U.P.) PLoS One. 2017; 12(3): 0174752. 

    Agmon-Levin N, Dagan A, Peri Y, Anaya JM, Selmi C, Tincani A, Bizzaro N, Stojanovich L, Damoiseaux J, Cohen Tervaert JW, Mosca M, Cervera R, Shoenfeld Y. The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: another angle of the autoimmune mosaic. Clin Exp Rheumatol. 2017;35(6):929-935.

    Oshagbemi OA, Burden AM, Braeken DCW, Henskens Y, Wouters EFM, Driessen JHM, Maitland-van der Zee AH, de Vries F, Franssen FME. Stability of Blood Eosinophils in Patients with Chronic Obstructive Pulmonary Disease and in Control Subjects, and the Impact of Sex, Age, Smoking, and Baseline Counts. Am J Respir Crit Care Med. 2017;195(10):1402-1404.

    Kuiper GJAJM, Houben R, Wetzels RJHVerhezen PWM, Oerle RV, Ten Cate H, Henskens YMC, Lancé MD. The use of regression analysis in determining reference intervals for low hematocrit and thrombocyte count in multiple electrode aggregometry and platelet function analyzer 100 testing of platelet function. Platelets. 2017;28(7):668-675.

    Hilderink JM, Rennenberg RJMW, Vanmolkot FHM, Bekers O, Koopmans RP, Meex SJR. Labtracker+, a medical smartphone app for the interpretation of consecutive laboratory results: an external validation study. BMJ Open. 2017;7(9):e015854.

    Smolders J, Rolf L, Damoiseaux J, Hupperts R. On the ethics of not supplementing low 25-hydroxyvitamin D levels in a controlled study in relapsing remitting multiple sclerosis. J Neurol Sci. 2017;15;379:331.

    Rolf L, Muris AH, Bol Y, Damoiseaux J, Smolders J, Hupperts R. Vitamin D3 supplementation in multiple sclerosis: Symptoms and biomarkers of depression. J Neurol Sci. 2017;378:30-35.

    Olie RH1, Meertens NEL, Henskens YMC, Ten Cate H. Empirically Reduced Dosages of Tinzaparin in Patients with Moderate-to-Severe Renal Insufficiency Lead to Inadequate Anti-Xa Levels. Nephron. 2017;137(2):113-123.

    van der Linden N, Streng A.S, Wodzig WK, Bekers O, Meex SJ. Better, higher, lower, faster: increasingly rapid clinical decision making using high-sensitivity cardiac troponin assays. J Lab Precis Med. 2017; 2:14.

    Vanderlocht J, van der Cruys M, Stals F, Bakker-Jonges L, Damoiseaux J. Multiplex autoantibody detection for autoimmune liver diseases and autoimmune gastritis. J Immunol Methods. 2017;448:21-25.

    Holwerda AM, Lenaerts K, Bierau J, Wodzig WKWH, van Loon LJC. Food ingestion in an upright sitting position increases postprandial amino acid availability when compared with food ingestion in a lying down position.  Appl Physiol Nutr Metab. 2017;42(7):738-743.

    Slot MC, Kroon AA, Damoiseaux JGMC, Theunissen R, Houben AJHM, de Leeuw PW, Tervaert JWC. CD4+CD28null T Cells are related to previous cytomegalovirus infection but not to accelerated atherosclerosis in ANCA-associated vasculitis. Rheumatol Int. 2017;37(5):791-798.

    Deenstra, D., Wolvetang, N., Kock, S., Wills, S., Cobben, N., Wijnen, P. & Drent, M. Prevalence of interstitial and other lung diseases on Aruba. Sarcoidosis Vasc dif 2017; 34, 3, p. 217-225 9.

    Kusters RW, Simons AP, Lancé MD, Ganushchak YM, Bekers O, Weerwind PW. Blood warming, pump heating and haemolysis in low-flow extracorporeal life support; an in vitro study using freshly donated human blood.Perfusion. 2017;32(1):27-34.

  • Publicaties 2016

    Turro E, Greene D, Wijgaerts A, Thys C, LentaigneC, Bariana T, Westbury SK, Henskens Y (collaborator) et al. A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.. Sci Transl Med 2016; 8: 328-30. IF 16.264

    Marsch E, Demandt JA, Theelen TL, Tullemans BM, Wouters K, Boon MR, Meex SJ et al. Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia.. Eur Heart J 2016; 37 (39): 2993-2997. IF 15.064

    Simeoni I, Stephens JC, Hu F, Deevi SV, Megy K, Bariana TK, Lentaigne C, Henskens YM,  et al. A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.. Blood 2016; 127 (23):2791-803. IF 11.847

    Elena Csernok,Jan Damoiseaux, Niels Rasmussen, Bernhard Hellmich Pieter van Paassen, Pieter Vermeersch, Daniel Blockmans, Jan-Willem Cohen Tervaart, Xavier Bossuyt. Evaluation of automated multi-parametric indirect immunofluorescence assays to detect anti-neutrophil cytoplasmic antibodies (ANCA) in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA).).  Autoimm Rev 2016; 15 (7): 736-41. IF 8.490

    Linda Rolf, Jan Damoiseaux, Raymond Hupperts, Inge Huitinga, Joost Smolders. Network of nuclear receptor ligands in multiple sclerosis: Common pathways and interactions of sex-steroids, corticosteroids and vitamin D3-derived molecules.Autoimmun Rev 2016; 15 (9): 900-10. IF 8.490

    Klinkenberg LJ, Wildi K, van der Linden N, Bekers O, van Dieijen-Visser MP, Meex SJ, Bons J et al. Diurnal Rhythm of Cardiac Troponin: Consequences for the Diagnosis of Acute Myocardial Infarction.. Clin Chem 2016; 62 (12): 1602-1611. IF 7.457

    Mattheij NJ, Swieringa F, Mastenbroek TG, Berny-Lang MA, May F, Baaten CC, van der Meijden PE, Henskens YM, Beckers EA, et all. Coated platelets function in platelet-dependent fibrin formation via integrin αIIbβ3 and transglutaminase factor XIII.. Haematologica 2016; 101 (4): 427-436. IF.6.671

    Swieringa F, Baaten CC, Verdoold R, Mastenbroek TG, Rijnveld N, Van der Laan KO, Breel EJ, Collins PW, Lancé MD, Henskens YM, Cosemans JM, Heemskerk JW, Van der Meijden PE. Platelet Control of Fibrin Distribution and Microelasticity in Thrombus Formation Under Flow.. Arterioscler Thromb Vasc Biol 2016; 36 (4): 692-9. IF 5.969

    DM Kimenai, RMA Henry, CJH van der Kallen, PC Dagnelie, MT Schram, CDA Stehouwer, O Bekers, S MeexMP van Dieijen-Visser. Direct comparison of clinical decision limits for cardiac troponin T and I.. Heart 2016; 102 (8): 610-6. IF 5.693

    Zegers CM, Hoebers FJ, van Elmpt W, Bons J. et al. Evaluation of tumor hypoxia during radiotherapy using [18F] HX4 PET imaging and blood biomarkers in patients with head and neck cancer. Eur J Nucl Med Mol Imaging 2016; 43 (12): 2139-2146. IF 5.537

    Groen BB, Horstman AM, Hamer HM, de Haan M, van Kranenburg J, Bierau J, Poeze M, Wodzig WK,Rasmussen BB, van Loon LJ. Increasing Insulin Availability Does Not Augment Postprandial Muscle Protein Synthesis Rates in Healthy Young and Older Men.  J Clin Endocrinol Metab 2016, 101 (11): 3978-3988. IF 5.531

    Huskens D, Roest M, Remijn JA Konings J, Kremers RM, Bloemen S, Meex SJ, et al. Strenuous exercise induces a hyperreactive rebalanced haemostatic state that is more pronounced in men. 2016; 115 (6): 1109-19. IF 5.255

    Vries MJ, van der Meijden PE, Henskens YM, Ten Cate-Hoek AJ, Ten Cate HAssessment of bleeding risk in patients with coronary artery disease on dual antiplatelet therapy. A systematic review. Thromb Haemost 2016 115(1):7-24. IF 5.255

    Carvalho S, Troost EGC, Bons J, Menheere P, Lambin P. Oberije C. Prognostic value of blood-biomarkers related to hypoxia, inflammation, immune response and tumour load in non-small cell lung cancer - A survival model with external validation. Radiother Oncol 2016; 119 (3):487-94. IF 4.817

    Van der Linden N,Cornelis T, Klinkenberg LJ, Kimenai DM, Hilderink JM,Litjens EJ, Kooman JP, Bekers O, van Dieijen-Visser MP, Meex, SJ.Strong diurnal rhythm of troponin T, but not troponin I, in a patient with renal dysfunction.. Int J Cardiol 2016; 221: 287-8. IF 4.638

    SHM Kleijkers, APA van Montfoort, O Bekers, E Coonen,  JG Derhaag, JLH Evers, JCM Dumoulin.  Ammonium accumulation in commercially available embryo culture media and protein supplements during storage at 2-8°C and during incubation at 37°C.Hum Reprod 2016; 31 (6): 1192-9. IF 4.621

    Smulders MW, Kietselaer BL, Schalla S, Bucerius J, Jaarsma C, van Dieijen-Visser MP, Mingels AM, Rocca HP, Post M, Das M, Crijns HJ, Wildberger JE, Bekkers SC. Acute chest pain in the high-sensitive cardiac troponin era: a changing role for non-invasive imaging? Am Heart J 2016; 177: 102-11. IF 4.332

    Rolf L, Muris AH, Hupperts R, Damoiseaux J. Illuminating vitamin D effects on B cells--the multiple sclerosis perspective. Immunology. 2016; 147 (3): 275-84. IF 4.078

    Anne-Hilde Muris, Linda Rolf, Kelly Broen, Raymond Hupperts, Jan Damoiseaux, Joost Smolders A low vitamin D status at diagnosis is associated with an early conversion to secondary progressive multiple sclerosis.J Steroid Biochem Mol Biol 2016; 164: 254-257. IF 3.985

    Wilde B, Mertens A, Arends SJ, Rouhl RP, Bijleveld R, Huitema J, Timmermans SA, Damoiseaux J,Witzke O, et al. Endothelial progenitor cells are differentially impaired in ANCA-associated vasculitis compared to healthy controls. Arthritis Res Ther 2016; 18: 147. IF 3.979

    Streng AS, de Boer D,Bouwman FG, Mariman EC, Scholten A, van Dieijen-Visser MP,  Wodzig WK.Development of a targeted selected ion monitoring assay for the elucidation of protease induced structural changes in cardiac troponin T.. J Proteomics 2016; 136: 123-32. IF 3.867

    K Rieswijk, SMH Claessen, O Bekers, M van Herwijnen, DHJ Theunissen, DGJ Jennen, et all. Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology 2016; 350-352: 31-9. IF 3.817

    AM Holwerda, IWK Kouw, J Trommelen, SL Halson, WKWH Wodzig, LB Verdijk, LJC van Loon. Physical Activity Performed in the Evening Increases the Overnight Muscle Protein Synthetic Response to Presleep Protein Ingestion in Older Men..  J Nutr 2016: 146 (7):1307-14. IF 3.740

    Van Poucke, Stevens K, Wetzels R, Kicken C, Verhezen P, Theunissen M, Kuiper G, van Oerle R, Henskens Y, Lancé M. Early platelet recovery following cardiac surgery with cardiopulmonary bypass.Platelets 2016; 27 (8): 751-757. IF 3.213

    Lieke Klinkenberg, Peter Luyten, Noreen vd Linden, Kim Urgel, Bastiaan Kietselaer, Alma Mingels, Eline Cardinaels, Joop ten Kate, Otto Bekers, Marja van Dieijen-Visser, Steven Meex et al. Cardiac Troponin T and I Release After a 30-km Run. Am J Cardiol 2016; 118 (2): 281-7. IF 3.154

    Kemna MJ, Schlumberger W, van Paassen P, Dähnrich C, Damoiseaux JGCohen Tervaert JW. The avidity of PR3-ANCA in patients with granulomatosis with polyangiitis during follow-up. Clin Exp Immunol 2016; 185 (2): 141-7. IF 3.148

    Cardinaels EP,Altintas S, Versteylen MO, Joosen IA, Jellema LJ, Wildberger JE, Bekers O, van Dieijen-Visser MP, Mingels AMet al. High-Sensitivity Cardiac Troponin Concentrations in Patients with Chest Discomfort: Is It the Heart or the Kidneys As Well? PLoS One 2016; 11 (4): e0153300. IF 3.057

    Muris AH, Smolders J, Rolf L, Klinkenberg LJ,  van der Linden N, Meex S, Damoiseaux J, Hupperts R. Vitamin D Status Does Not Affect Disability Progression of Patients with Multiple Sclerosis over Three Year Follow-Up. PLoS One 2016; 11 (6). IF 3.057

    Van Beers JJ, van Egmond LT, Wetzels RJ, Verhezen PW, Beckers EA, van Oerle R, Spronk HM, Straat RJ, Henskens YM. Increased coagulation and fibrinolytic potential of solvent-detergent plasma: a comparative study between Omniplasma and fresh frozen plasma.Vox Sang 2016; 111 (1): 33-42. IF 2.656

    Muris AH, Smolders J, Rolf L, Thewissen M, Hupperts R, Damoiseaux J.Immune regulatory effects of high dose vitamin D<sub>3</sub> supplementation in a randomized controlled trial in relapsing remitting multiple sclerosis patients receiving IFNβ; the SOLARIUM study.. J Neuroimmunol 2016; 300: 47-56. IF 2.536

    Smolders J, Muris AH, Damoiseaux J. Immunomodulation by vitamin D in multiple sclerosis: More than IL-17.: J Neuroimmunol 2016; 292: 79-80. IF 2.536

    Altintas S, Cardinaels EP, Versteylen MO, Joosen IA, Seifert M, Wildberger JE, van Dieijen-Visser MP, Mingels AMet al. Unstable coronary plaque characteristics are associated with high-sensitivity cardiac troponin T and N-terminal Pro-Brain Natriuretic Peptide.J Cardiovasc Comput  Tomogr 2016; 10 (1): 82-8. IF 2.472

    T Berge, IS Leikfoss, IS Brorson, SD Bos, CM Page, MW Gustavsen, J Damoiseaux et all. The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells. Genes Immun 2016; (17): 118-27. IF 2.472

    Streng AS, de Boer D, van Doorn WP,Kocken JM, Bekers O, Wodzig WK.Cardiac troponin T degradation in serum is catalysed by human thrombin.Biochem Biophys Res Commun 2016; 481 (1-2): 165-168. IF 2.371

    Eijgenraam P, Ten Cate H, Henskens Y, van den Ham R, Ten Cate-Hoek A. Effects of peri-operative bridging with low molecular weight heparins on coagulation during interruption of vitamin K antagonists: A mechanistic study.: A mechanistic study. Thromb. Res. 2016; 140: 59-65. IF 2.320

    TY Avery, J Bons, P van Paassen, J Damoiseaux. Diagnostic ANCA algorithms in daily clinical practice: evidence, experience, and effectiveness.. Lupus 2016; 25 (8): 917-24. IF 2.118

    E. Chan, J Damoiseaux, W de Melo Cruvinel, O Carballo, K Conrad et al. Report on the second International Consensus on ANA Pattern (ICAP) workshop in Dresden 2015.. Lupus 2016; 25 (8): 797-804. IF 2.118

    Boersma RS, Hamulyak K, van Oerle R, Tuinenburg A, Cate-Hoek AJ, Schouten HC Biomarkers for Prediction of Central Venous Catheter Related-Thrombosis in Patients With Hematological Malignancies. Clin Appl Thromb Hemost. 2016; 115 (1): 7-24. IF 1.973

    Kusters RW, Simons AP, Lancé MD, Ganushchak YM, Bekers O, Weerwind PW. Blood warming, pump heating and haemolysis in low-flow extracorporeal life support; an in vitro study using freshly donated human blood.Perfusion 2017; 32 (1): 27-34. IF 1.442

  • Publicaties 2015

    Kemna, M.J., J.G.M.C. Damoiseaux, J. Austen, B. Winkens, J. Peters, P. van Paassen, and J.W. Cohen Tervaert . ANCA as a predictor of relapse: useful in patients with renal involvement but not in patients with nonrenal disease. J Am Soc Nephrol 26: 537-542. IF 9.343

    Damoiseaux, J.G.M.C., L.E. Andrade, M.J. Fritzler, and Y. Shoenfeld (2015). Autoantibodies 2015: from diagnostic biomarkers toward prediction, prognosis and prevention. Autoimmun Rev 2015; 14: 555-563. IF 7.933

    Jacobs, J.F.M., R.G. van der Molen, X. Bossuyt, and J.G.M.C. DamoiseauxAntigen excess in modern immunoassays: to anticipate on the unexpected. Autoimmun Rev. 2015 14: 160-167. IF 7.933

    Baaten CC, Veenstra LF, Wetzels R, van Geffen JP, Swieringa F, de Witt SM, Henskens YM, Crijns H, Nylander S, van Giezen JJ, Heemskerk JW, van der Meijden PE. Gradual increase in thrombogenicity of juvenile platelets formed upon offset of prasugrel medication. Haematologica 2015; 100 (9):1131-1138. IF 5.814

    Loeffen R, Godschalk TC, van Oerle R, Spronk HM, Hackeng CM, ten Berg JM, ten Cate H. The hypercoagulable profile of patients with stent thrombosis. Heart. 2015 Jul; 101(14): 1126-1132.  IF 5.595

    Van der Linden N, Klinkenberg LJJ, Leenders M, Tieland M, Bekers O, Van Dieijen-Visser MP  et all. The effect of exercise training on the course of cardiac troponin T and levels: three indipendent training studies. Scientific Reports 2015; 5: 6- IF 5.578

    Knapen MH, Braam LH, Drummen NE, Bekers O, Hoeks AP, Vermeer C. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. Thromb Haemost 2015; 113 (5): 1135-1144. IF 4.984

    Swieringa F, Lancé MD, Fuchs B, Feijge MA, Solecka BA, Verheijen LP, Hughes KR, van Oerle R, Deckmyn H, Kannicht C, Heemskerk JW, van der Meijden PE. Desmopressin treatment improves platelet function under flow in patients with postoperative bleeding.J Thromb Haemost. 2015 Aug;13(8):1503-1513. IF 4.984

    E Cardinaels, M Daamen, O Bekers, J ten kate, M Niens, J van Suijlen, M van Dieijen-Visser, H-P Brunner la Rocca, J Schols, A Mingels. Clinical interpretation of elevated concentrations of cardiac troponin T, but not troponin I, innursing home residents. J Am Med Dir Assoc. 2015; 16 (10): 884-891. IF 4.939

    Spronk HM,  Braunschweig T,  Rossaint R, Wüst DC, van Oerle R, Lauritzen B, Tolba R, Grottke O. Recombinant Factor VIIa Reduces Bleeding after Blunt Liver Injury in a Pig Model of Dilutional Coagulopathy under Severe Hypothermia. PLoS One. 2015 Jun 22; 10(6): e0113979. IF 3.234

    Groen B, Horstman A, Hamer H, de Haan M, van Kranenburg J,  Bierau J, Poeze M, Wodzig W, Rasmussen B, van Loon L. Post-prandial protein handling: you are what you just ate. PLoS One. 2015; 10 (11): e0141582. IF 3.234

    E Cardinaels, T Cornelis, F van der Sande, K Leunissen, M van Dieijen-VisserA Mingels, J Kooman, O BekersAcute effects of conventional and extended hemodialysis and hemodiafiltration on high-sensitivity cardiac troponins. Clin Chem Lab Med. 2015; 53 (11): e289-292. IF 2.707

    Timmermans, SAMEG., MA Abdul Hamid, JW Cohen Tervaert, JGMC Damoiseaux, P van Paassen, Anti-PLA2R antibodies as a prognostic factor in PLA2R-related membranous nephropathy. Am. J. Nephrol. 2015; 42: 70-77. IF 2.669

    Kicken C, Van Poucke S, Marcus AE, Lance MD, Henskens Y. Response of platelet concentrates to pressure and temperature changes without impairment of the in vitro function. Thromb Res 2015; 135 (4): 679-683. IF 2.447

    Daamen M, Hamers JPH, Gorgels APM, Brunner-La Rocca HP, Tan FES, Van Dieijen-Visser MP, Schols J. Heart failure in nursing home residents; a cross-sectional study to determine the prevalence and clinical characteristics. MBC Geriatrics 2015; 15: 9- IF 1.676

    Ten Cate-Hoek AJ, Ten Cate H, Henskens Y, van der Meijden PE, Spronk HM, Wittens C. Maastricht consensus conference on thrombosis (MCCT): a roadmap for future research. Thromb Res 2015; 136: S1-2 IF 2.447

    Chan E.K.L., J.G.M.C. Damoiseaux, O.G. Carballo, K. Conrad, W. de Melo Cruvinel, P.L. Carvalho Francescantonio, M.J. Fritzler, I. Garcia-De La Torre, M. Herold, T. Mimori, M. Satoh, C.A. von Mühlen, and L.E.C. Andrade (2015). Report of the first international consensus on standardized nomenclature of antinuclear antibody HEp-2 cell patterns 2014-2015. Front. Immunol. 6: 412.

    Buitrago L, Rendon A, Liang Y, Simeoni I, Negri A. Ouwehand W, Henskens Y, Vries M et all. Allbbeta3 variants defined by next-generation sequencing: Predicting variants likely to cause Glanzmann thrombastenia. Poc Natl Acad Sci USA 2015, Apr 14; 112 (15): E1898-E1907

    Peelen, E., J.G.M.C. Damoiseaux, A.-H. Muris, S. Knippenberg, J. Smolders, R. Hupperts, and M. Thewissen (2015). Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis. Mol Immunol 2015; 63: 521-529. IF 2.973

    Van den Hof WF, Ruiz-Aracama, Van Summeren A, Jennen DG, Gaj S, Coonen ML, Brauers K, Wodzig WK, van Delft JH, Kleinjans JC. Integrating multiple omics to unravel mechanisms of cyclosporin a induced hepatotoxicity in vitro. Toxicol in vitro 2015; 29 (3): 489-501. IF 2.903

    Peelen, E., A.-H. Muris, J.G.M.C. Damoiseaux, S. Knippenberg, K. Broen, J. Smolders, J.W. Cohen Tervaert, R. Hupperts, and M. Thewissen. GM-CSF production by CD4+ T cells in MS patients: regulation by regualtory T cells and vitamin D. J Neuroimmunol 2015; 280: 36-42. IF 2.467

    Wanda M. de Raadt, Petal A. Wijnen, Aalt Bast, Otto Bekers, Marjolein Drent. Acute easinophilic pneumonia associated with glyphosate surfactant exposure. Sarcoidosis vasc dif 2015; 32 (2): 172-175. IF 1.169

    Keijzers, M, J.G.M.C. Damoiseaux, A. Vigneron, N. Bodart, A. Kessels, A.-M.C. Dingemans, M. Hochstenbach, J. Maessen, and M. DeBaets (2015). Do associated auto-antibodies influence the outcome of myasthenia gravis after thymectomy? Autoimmunity 2015; 48 (8): 552-555. IF 2.714

    Pagter, A.P.J. de, R.G.M. Bredius, T.W. Kuijpers, J. Tramper, M. van der Burg, J. van Montfrans, G.J. Driessen, on behalf of the Dutch Working Party for Immunodeficiencies (including J.G.M.C. Damoiseaux, 2015). Overview of 15-year severe combined immunodeficiency in the Netherlands: towards newborn blood spot screening. Eur. J. Pediatr. 174: 1183-1188. IF 1.890

  • Publicaties 2014

    Agmon-Levin N, Damoiseaux J, Kallenberg C, Sack U, Witte T, Herold M, Bossuyt X, Musset L, Cervera R, Plaza-Lopez A, Dias C, Sousa MJ, Radice A, Eriksson C, Hultgren O, Viander M,  Khamashta M,  Regenass S, Coelho Andrade LE, Wiik A, Tincani A, Rönnelid J, Bloch DD, Fritzler MJ, Chan EKL, Garcia-De La Torre I, Konstantinov KN, Lahita R, Wilson M,  Vainio O, Fabien N, Sinico RA, Meroni P, Shoenfeld Y. International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies. Ann Rheum Dis 2014: 73 (1): 17-23.

    Avery, T.Y., M. van de Cruys, J. Austen, F. Stals, and J.G.M.C. Damoiseaux (2014). Anti-nuclear antibodies in daily clinical practice: prevalence in primary, secondary, and tertiary care. Immunol. Res. 2014;  ID 401739.

    Blerk, M. van, X. Bossuyt, R. Humbel, A. Mewis, G. Servais, J.P. Tomasi, C. van Campenhout, L. van Hoovels, M. Vercammen, J.G.M.C. Damoiseaux, W. Coucke, and P. van de Walle (2014). Belgian recommendations on ANA, anti-dsDNA and anti-ENA antibody testing. Acta Clinica Belgica 69: 83-86.

    Bock, L. de, K. Somers, J. Fraussen, J.J.A. Hendriks, J. van Horssen, M. Rouwette, N. Hellings, L.M. Villar, J.C. Álvarez-Cermeño, M. Espiño, R. Hupperts, P. Jongen, J.G.M.C. Damoiseaux, M.M. Verbeek, P.P. de Deyn, M. D’hooghe, B. van Wijmeersch, P. Stinissen, and V. Somers. Sperm-associated antigen 16 is a novel target of the humoral autoimmune response in multiple sclerosis. J. Immunol. 2014; 193: 2147-2156.

    Buijsen J, van Stiphout RG, Menheere PP, Lammering G, Lambin P. Blood biomarkers are helpful in the prediction of response to chemoradiation in rectal cancer: a prospective, hypothesis driven study on patients with locally advanced rectal cancer. Radiother Oncol 2014; 111 (2):237-42.

    Cornelis, T. F.M. van der Sande, S. Eloot, E. Cardinaels, O. BekersJ.G.M.C. Damoiseaux, K.M. Leunissen, and J.P. Kooman. Acute hemodynamic response and uremic toxin removal in conventional and extended hemodialysis and hemodiafiltration: a randomized crossover study. Am. J. Kidney Dis. 64: 247-256.

    Cornelis T, Broers NJ, Titulaer DC, Henskens YM, van Oerle R, van der Sane FM, Vink H, Leunissen KM, Ten Cate H. Kooman JP. Effects of Ultrapure Hemodialysis and Low Molecular Weight Heparin on the Endothelial Surface Layer. Blood purif 2014; 38 (3-4): 203-210. Damoiseaux, J.G.M.C.The diagnosis and classification of the cryoglobulinemic syndrome. Autoimmunity Rev. 2014; 13: 359-362.

    Damoiseaux, J.G.M.C., and J.W. Cohen Tervaert (2014). Diagnostics and treatment of cryoglobulinaemia: it takes two to tango. Clin. Rev. Allerg. Immunol. 2014; 47: 299-310.

    Damoiseaux, J.G.M.C., N. Agmon-Levin, M. van Blerk, V. Chopyak, C. Eriksson, I. Heijnen, M. Herold, K. Høgåsen, L. Musset, A. Radice, M.J. Rego de Sousa, M. Viander, and Y. Shoenfeld. From ANA-screening to antigen-specificity: an EASI-survey on the daily practice in European countries. Clin. Exp. Rheumatol. 2014; 32: 539-546.

    De Lange NM, van Rheenen-Flach LE, Lancé MD, Mooyman L, Woiski M, van Pampus EC, Porath M, Bolte AC, Smits L, Henskens YM, Scheepers HC. Peri-partum reference ranges for ROTEM(R) thromboelastometry. Br J Anaesth 2014; 112 (5): 852-9.

    Kleinegris MC, Bos MH, Roest M, Henskens Y, Ten Cate-Hoek A, Van Deursen C, Spronk HM,  Reitsma PH, De Groot PG, Ten Cate H, Koek, Cirrhosis patients have a coagulopathy that is associated with decreased clot formation capacity. Thromb Haemost 2014; 12 (10): 1647-57.

    Klinkenberg LJ, van Dijk JW, Tan FE, van Loon LJ, van Dieijen-Visser MP, Meex SJ. Circulating cardiac troponin T exhibits a diurnal rhythm. J Am Coll Cardiol. 2014; 63(17): 1788-95.

    Knippenberg, S., J.G.M.C. Damoiseaux, Y. Bol, R. Hupperts, B.V. Taylor, A.L. Ponsonby, T. Dwyer, S. Simpson, and I.A. van der Mei (2014). Higher levels of reported sun exposure, and not vitamin D status, are associated with less depressive symptoms and fatigue in multiple sclerosis. Acta Neurol. Scand 2014; 129: 123-131.

    Loeffen R, R. van Oerle, P.G. de Groot, J. Waltenberger, H.J. Crijns, H. Spronk, H. ten Cate. Increased factor XIa levels in patients with a first acute myocardial infarction: the introduction of a new thrombin generation based factor XIa assay. Thrombosis Research 2014; 134: 1328-1334.

    Maas, T., C. Nieuwhof, V. Lima Passos, C. Robertson, A. Boonen, R.B. Landewé, J.W. Voncken, J.A. Knottnerus, and J.G.M.C. DamoiseauxTransgenerational occurrence of allergic disease and autoimmunity: general practice-based epidemiological research. Prim. Care Respir. J. 2014; 23: 14-21.

    Marsch E, Theelen TL, Demandt JA, Jeurissen M, van Gink M, Verjans R, Janssen A, Cleutjens JP, Meex SJ, Donners MM, Haenen GR, Schalkwijk CG, Dubois LJ, Lambin P, Mallat Z, Gijbels MJ, Heemskerk JW, Fisher EA, Biessen EA, Janssen BJ, Daemen MJ, Sluimer JC. Reversal of hypoxia in murine atherosclerosis prevents necrotic core expansion by enhancing efferocytosis.  Arterioscler Thromb Vasc Biol. 2014; 34(12): 2545-53.

    Meijer U,  de Jong JJ, Bours SG, Keszei AP, Arts JJ, Brink PR, Menheere PP, van Geel TA, van Rietbergen B, van den Bergh JP, Geussens PP, Willems PC. Early changes in bone density, microarchitecture, bone resorption, and inflammation predict the clinical outcome 12 weeks after conservatively treated distal radius fractures: an exploratory study.  J Bone Miner Res 2014; 29 (9): 2065-73.

    Olde Engberink RH, Kuiper GJ, Wetzels RJ, Nelemans PJ, Lance MD, Beckers EA, Henskens YMRapid and correct prediction of thrombocytopenia and hypofibrinogenemia with rotational thromboelastometry in cardiac surgery. J Cardiothorac Vasc Anesth 2014; 28 (2): 210-6.

    Pijls KE, de Vries H, Nikkessen S, Bast A, Wodzig WK, Koek GH. Critical appraisal of 13C breath tests for microsomal liver function: aminopyrine revisited. Liver Int. 2014; 34(4): 487-94.

    Loeffen R, R. van Oerle, P.G. de Groot, J. Waltenberger, H.J. Crijns, H. Spronk, H. ten Cate. Increased factor XIa levels in patients with a first acute myocardial infarction: the introduction of a new thrombin generation based factor XIa assay. Thrombosis Research 2014; 134: 1328-1334.

    Rocha-Parise, M., L.M. Santos, J.G.M.C. Damoiseaux, E. Bagatin, A.V. Lido, C.O. Torello, J.W. Cohen Tervaert, and M.L. Queiroz. Lymphocyte activation in silica-exposed workers. Int. J. Hyg. Environ. Health 2014; 217: 586-591.

    Rolf, L., A.-H. Muris, R. Hupperts, and J.G.M.C. Damoiseaux (2014). Vitamin D effects on B cell function in autoimmunity. Ann. N.Y. Acad. Sci.  2014; 1317: 84-91.

    Ross HA, Lentjes EW, Menheere PM, Sweep CG.  Harmonization of growth hormone measurement results: the empirical approach. Clin Chim Acta 2014; 432: 72-6.

    Smiet E, Van Dierendonck MC, Sleutjens J, Menheere PP, van Breda E, de Boer D, Back W, Wijnberg ID, van der Kolk JH. Effect of different head and neck positions on behaviour, heart rate variability and cortisol levels in lunged Royal Dutch Sport horses. Vet J 2014; 202 (1): 26-32.

    Smolders J, Peelen E, Thewissen M, Menheere P, Damoiseaux J, Hupperts R. Circulating vitamin D binding protein levels are not associated with relapses or with vitamin D status in multiple sclerosis. Mult Scler 2014; 20 (4): 433-7. 

    Streng AS, Jacobs LH, Schwenk RW, Cardinaels EP, Meex SJ, Glatz JF, Wodzig WK, van Dieijen-Visser MP.  Cardiac troponin in ischemic cardiomyocytes: intracellular decrease before onset of cell death. Exp Mol Pathol. 2014; 96(3):339-45.

    Timmermans, S.A.M.E.G., J.G.M.C. Damoiseaux, P.T.J. Heerings-Rewinkel, R. Ayalon, L.H. Beck, W. Schlumberger, D.J. Salant, P. van Paassen, and J.W. Cohen Tervaert. Evaluation of anti-PLA2R1 as measured by a novel ELISA in patients with idiopathic membranous nephropathy: a cohort study. Am. J. Clin. Pathol. 2014; 142: 29-34.

    Van den Hof WF, Coonen ML, van Herwijnen M, Brauers K, Wodzig WK, van Delft JH, Kleinjans JC. Classification of hepatotoxicants using HepG2 cells: A proof of principle study. Chem Res Toxicol. 2014; 27(3): 433-42.

    Van den Hof WF, Van Summeren A, Lommen A, Coonen ML, Brauers K, van Herwijnen M, Wodzig WK, Kleinjans JC. Integrative cross-omics analysis in primary mouse hepatocytes unravels mechanisms of cyclosporin A-induced hepatotoxicity. Toxicology. 2014; 324: 18-26.

    van der Linden N, Klinkenberg LJ, Meex SJ, Beckers EA, de Wit NC, Prinzen L. Immature platelet fraction measured on the Sysmex XN hemocytometer predicts thrombopoietic recovery after autologous stem cell transplantation. Eur J Haematol. 2014; 93(2): 150-6.

    Vlassaks E, M. Nikiforou, E. Strakx, M. Hutten, O. Bekers, D. Gazzolo, G. Li Volti, P. Martinez-Martinez, B.W. Kramer, W.D. Gavilanes. Acute and chronic immunomodulatory changes in rat liver after fetal and perinatal asphyxia. J Dev Orig Health Dis 2014; 5 (2): 98-108.

    Vogt MHJ, Bons JA, Janssen MJW, Naus A, Oosterhuis W, ten Kate J, Menheere PPCAA multicenter evaluation of dysthyroxinemia in a defined patient cohort. Clin Chem Lab Med 2014; 52 (8): 1153-8.

    Wester M, Simonis F, Lachkar N, Wodzig WK, Meuwissen FJ, Kooman JP, Boer WH, Joles JA, Gerritsen KG. Removal of urea in a wearable dialysis device: a reappraisal of electro-oxidation. Artif Organs 2014; 38(12): 998-1006.

    Wijnen PA, Cremers JP, Nelemans PJ, Erckens RJ, Hoitsma E, Jansen TL, Bekers O, Drent M. Association of the TNF-α G-308A polymorphism with TNF-inhibitor response in sarcoidosis. J 2014; 43 (6): 1730-9.

Medische Microbiologie

  • CAPHRI-projects

    Transmission mechanisms of antimicrobial resistance and bacterial strains

    Resistance of bacteria against antibiotics is rising to dangerously high levels in all parts of the world. New resistance mechanisms are emerging and spreading globally. Drugs that were once lifesavers are now useless and the treatment of many infectious diseases is becoming harder, and sometimes even impossible. With a lack in the development of novel antibiotics, the conservation of existing ones is crucial. Using molecular epidemiological approaches and several molecular typing and sequencing technologies, we study the emergence and spread of antimicrobial resistant (AMR) microorganisms and their mobile genetic elements. Such surveillance of AMR is of crucial importance in order to detect resistant strains of public health importance at an early stage and support the timely notification and investigation of outbreaks.

    Role in infection control within and between medical care institutions

    Molecular epidemiology of antimicrobial resistant bacteria and mobile genetic elements

    Public Health and sexually transmitted diseases

  • NUTRIM-projects

    The human microbiome

    The billions of microbes that colonize the human body are collectively referred to as the microbiome. Most microorganisms inhabit our gastrointestinal tract, but also the skin, urogenital tract, and the respiratory tract are colonized by a wide variety of microbes.

    The human microbiome plays a key role in human health by providing a natural barrier against pathogen colonization, supporting the provision of nutrients and exerting a critical role in shaping the mucosal immune system. Moreover, metabolites and innate immune stimuli produced by enteric microbes have numerous effects beyond the site of microbial colonization. Understanding what defines a healthy microbiome is fundamental to maintain healthy living and prevent disease development. 

    Our department has a long track record on microbiome research that goes back to the early 1990’s, long before microbiome research became such a booming field of science. At present, microbiome research at our department is at the international forefront with on-site automated sample processing, next-generation sequencing facilities and extensive bioinformatic expertise. The microbiome research group has strong links with clinical departments within our MUMC+ and is involved in many national and international research consortia, including the ambitious Million Microbiomes of Humans Project. 

    To further strengthen our Euregional collaboration on microbiome research and cross borders between research disciplines, we recently initiated the Euregional Microbiome Center (microbiomecenter.eu) together with research groups at Maastricht University Campus Venlo, Uniklink RWTH Aachen and the University of Liège.

    There are three main themes within the microbiome research group.

    1. Development of a healthy microbiome
      In order to understand which dietary, environmental and host factors contribute to the development of a healthy microbiome, we study the microbiome establishment from birth onwards within the context of many population-based birth cohorts. By profiling the microbiome of thousands of babies, toddlers, children and adults, we aim to understand what drives the inter-individual variation in microbiota composition and function and how this relates to a healthy life. Next to these observational studies in humans, mechanistic in vivo and in vitro studies are conducted to understand the interactions between the microbiota, diet and the host. 
      This research line is embedded within large national and international consortia such as the NWO Carbohydrate Competence Center, the JPI Healthy Diet for a Healthy Life and the World Universities Network inVivo Planetary Health. Contract research with (international) companies as well collaboration with microbiome related institutions are part of our research program.
    2. The microbiome in health, disease and routine patient care
      Next to maintaining a healthy microbiome for a healthy life, the microbiome is a target for treatment of already manifested diseases by the application of functional food ingredients, viable bacteria (probiotics), fecal transplant strategies or novel drugs and constitutes of a pool of innovative non-invasive diagnostic and prognostic biomarkers. In close collaboration with many clinical departments within our MUMC+ as well as across the world, we examine the role of the microbiome and microbial components, such as membrane vesicles, in a wide variety of diseases, including chronic intestinal diseases (Inflammatory Bowel Disease, Irritable Bowel Syndrome), metabolic diseases (overweight and obesity, type 2 diabetes), chronic respiratory diseases (COPD, asthma) and several types of cancer. Automated rapid technologies and Artificial Intelligence algorithms are studied for clinical purpose and improvement of patient care, e.g. to predict and/or prevent exacerbations and optimize treatment in an early phase based on defined changes in the microbiome composition.
      In recent years, it has become apparent that the microbiome also has a significant influence on treatment drugs as specific microbes can convert drugs into active, inactive or even toxic components. We therefore also study the impact of the microbiome on treatment response.
    3. The microbiome as a reservoir of antimicrobial resistance
      Although the extensive overuse and misuse of antibiotics in both humans and animals is mainly fueling AMR, it is the increased globalization that subsequently results in rapid dissemination of (novel) AMR bacteria or bacterial mobile genetic elements from AMR hot zones, such as South and Southeast Asia, to other parts of the world. 
      The intestinal microbiome is the most important reservoir through which these travelers to AMR hot zones may acquire and import AMR. The gastrointestinal tract is an open system, which every day encounters a myriad of bacterial acquisitions originating from the environment (e.g. from food, water, soil, and other humans or animals. These incoming bacteria acquired in countries with a high prevalence of AMR often harbor antibiotic resistance genes. Consequently, local emergence of AMR can rapidly become a worldwide health problem.
      Within our department, we study the impact of migration (including tourists, business travelers, students and refugees) on the import and spread of AMR. We are amongst others coordinating the worldwide largest study on the Carriage Of Multidrug resistant Bacteria After Travel (COMBAT-study). Using a combination of metagenomic approaches, we mine the gut microbiome to reveal potential novel AMR genes. This is not only done in travelers, but also in local populations, the environment and livestock in countries with a high prevalence of AMR (e.g. India and Vietnam).
  • i-4-1-Health
    Logos

    In de grensstreek Vlaanderen-Nederland werken negen ziekenhuizen, zeven publieke gezondheidsdiensten, zeven kennisinstellingen en drie bedrijven samen aan het i-4-1-Health-project. Dit project richt zich op infectiepreventie en het bestrijden van antibioticaresistentie bij mens en dier (One Health) door middel van onderzoek en innovatie. Het project start op 1 januari 2017 en duurt tot en met 31 december 2019. Het Amphia Ziekenhuis is de projectverantwoordelijke organisatie en het Universitair Ziekenhuis Antwerpen is co-projectverantwoordelijk.

    Meer informatie over het i-4-1-Health-project is te vinden op: www.i41Health.eu.

    Rol van het academisch ziekenhuis Maastricht in dit project

    De afdeling Medische Microbiologie van het academisch ziekenhuis Maastricht (onderdeel van het Maastricht UMC+) is werkpakketleider van Werkpakket 7 ‘Track en Trace van resistente Bacteriën (Whole Genome sequencing platform)’. WP7 focust op het in kaart brengen van de aanwezigheid en het volgen van de verspreiding van antimicrobiële resistentie en van de micro-organismen die deze resistentie dragen in de veehouderij, in de publieke gezondheidssector en in de zorg. De procedure omvat alle stappen van monstername en wet-lab analyses (door academisch ziekenhuis Maastricht, Universiteit Antwerpen en Universitair Ziekenhuis Antwerpen) tot bio-informatica-gestuurde interpretatie van de data.

    Interreg Vlaanderen-Nederland

    Het i-4-1-Health-project is gefinancierd binnen het Interreg V-programma Vlaanderen-Nederland. Dit is een grensoverschrijdend samenwerkingsprogramma met financiële steun van het Europees Fonds voor Regionale Ontwikkeling.

    Meer informatie over het Interreg Vlaanderen-Nederland-programma is te vinden op: www.grensregio.eu.

  • euPrevent COVID-19
    interreg

    Sinds de uitbraak in december 2019 heeft COVID-19 de hele wereld getroffen, inclusief Europa. Het heeft dus ook veel invloed gehad op de Euregio Maas-Rijn. Momenteel is de kennis over de verspreiding van de COVID-19 in de bevolking in relatie tot het wel of niet naleven van de infectiepreventiemaatregelen beperkt. Dit is echter wel de basis om de ziekte te kunnen monitoren en indien noodzakelijk maatregelen op te leggen of juist op te heffen. Dit project is ontwikkeld om gegevens te verzamelen over het voorkomen van COVID-19 en hoe dit zich verhoudt tot het gedrag van de bevolking in alle drie de landen van de EMR.

    Projectkader

    Definitieve doelgroep: EMR burgers
    Duur van het project: 1 augustus 2020 - 31 juli 2021
    Hoofdfinancier: Interreg EMR
    Projectpartners: GGD Zuid-Limburg, euPrevent EMR, Sciensano, Maastricht UMC+, Gesundheitsamt des Kreises Heinsberg, Gesundheitsamt Düren, Gesundheitsamt der Städte Region Aachen, Deutschsprachige Gemeinschaft Belgiens

    Focus van het project

    Het doel van het project is om de impact van COVID-19 op de EMR te beoordelen: door het voorkomen van COVID-19 antilichamen te relateren aan de genomen maatregelen, zodat inzicht wordt verkregen in de effecten van COVID-19 in een grensoverschrijdende regio als de EMR. Dit wordt ook gepresenteerd als een showcase voor andere grensregio's in de EU (of zelfs breder).

    Activiteiten

    • Er zullen in twee rondes bloedmonsters worden afgenomen en geanalyseerd om de ontwikkeling van COVID-19-antilichamen onder EMR-burgers te zien. Dit wordt in verband gebracht met de verschillende genomen maatregelen in de landen van de EMR.
    • Er zullen regionale burgertops worden georganiseerd om zo ook de stem van de burger mee te nemen. Middels deze burgertops wil het project inzicht krijgen in hoe zij COVID-19 hebben ervaren.
    • Er zal een conferentie worden georganiseerd waar de eerste resultaten van dit project zullen worden gepresenteerd en waar het rapport met de aanbeveling zal worden besproken met deskundigen uit de hele EMR en daarbuiten.

    Resultaten

    Naast het eindrapport welke de bevindingen van het onderzoek en de regionale burgertops omvat, zal een infographic worden gemaakt van het resultaat van het rapport voor een betere illustratie, en zullen alle gegevens die door het project zijn verkregen, worden gepresenteerd op de Euregional Health Atlas (EHA) (Euregionale Gezondheidsatlas).

    Lees verder op de website euPrevent

    projectpartners euPrevent Covid

Forensische en postmortale radiologie

  • Publicaties

    Clinical Relevance of Unexpected Findings of Post-Mortem Computed Tomography in Hospitalized Patients: An Observational Study. Mentink MG, Latten BGH, Bakers FCH, Mihl C, Rennenberg RJMW, Kubat B, Hofman PAM. Int J Environ Res Public Health. 2020 Oct 18;17(20):7572 Pubmed

    Introduction of postmortem CT increases the postmortem examination rate without negatively impacting the rate of traditional autopsy in daily practice: an implementation study. Mentink MG, Bakers FCH, Mihl C, Lahaye MJ, Rennenberg RJMW, Latten BGH, Kubat B, Hofman PAM. J Clin Pathol. 2020 Jul 16:jclinpath-2020-206734 Pubmed

Klinische Farmacie en Toxicologie/Apotheek

Meer informatie over wetenschappelijk onderzoek, uitgevoerd door onze afdeling kan gevonden worden op de researchwebsite van de Apotheek.

Pathologie

Meer informatie over onderzoek en publicaties van de afdeling pathologie vindt u hier.

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